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基于近红外光谱分析技术评价运动对老年人认知
作者:网站采编关键词:
摘要:背景:认知老化是增龄性相关的认知功能衰退,临床上目前没有明确的治疗原则可循,进入终末期发展成为认知功能障碍,运动延缓认知老化得到普遍认可。 目的:总结目前基于近红外
背景:认知老化是增龄性相关的认知功能衰退,临床上目前没有明确的治疗原则可循,进入终末期发展成为认知功能障碍,运动延缓认知老化得到普遍认可。
目的:总结目前基于近红外光谱分析技术评价运动延缓认知老化的进展和不足。
方法:遵循PRISMA 指南,由第一作者以“运动,近红外光谱,认知,老年人,组织蛋白酶B,脑源性神经营养因子”为中文检索词,以“exercise,near-infrared spectroscopy,cognition,elderly or older adults,cathepsin B,brain-derived neurotrophic factor”为英文检索词,对PubMed,WOS,CNKI,万方等数据库分别进行检索,对文献中基于近红外光谱技术的运动,老年人的认知功能的文献,保留37 篇文献进一步总结分析。
结果与结论:综合目前基于近红外光谱技术分析运动延缓认知老化的研究,证实运动改善不同脑区皮质的激活程度,进而改善认知功能。长期的有氧运动对认知功能改善的效果较短期运动优,更有利于延缓认知老化。其潜在的生理学机制可能在于运动改善大脑的血流灌注,其次运动刺激骨骼肌分泌神经营养因子,促进神经元的生长、存活、增殖。但干预方案无统一标准,诸多环节,如个体差异、不同脑区指标的结合,被试的身体状况(心血管疾病和肺部疾病)的测试程序均有待于进一步完善,提高参数的可靠性和有效性。
上海体育科学研究所课题(2017TKS002)
BACKGROUND:Cognitive aging is an age-related cognitive degeneration that can develop into a cognitive dysfunction in the end is no clear therapeutic principle in clinical practice,but it is generally recognized that exercises can delay cognitive aging.
OBJECTIVE:To summarize the current progress and shortcomings of exercise-delayed cognitive aging based on near-infrared spectroscopy.
METHODS:In line with the PRISMA guidelines,the first author searched PubMed,WOS,CNKI,and WanFang using the keywords of“exercise,near-infrared spectroscopy,cognition,elderly or older adults,cathepsin B,brain-derived neurotrophic factor”in Chinese and English, addressing senile cognitive function based on the near-infrared spectroscopy technique was retrieved,and 37 eligible articles were retained for further analysis.
RESULTS AND CONCLUSION:We performed a comprehensive analysis of exercise-delayed cognitive aging based on near-infrared spectroscopy and confirmed that exercise improves the activation of cortex in different brain regions and thus improves cognitive aerobic exercise has better effects in the improvement of cognitive function than short-term exercise,which is more conducive to delaying cognitive underlying physiological mechanism may be that exercise improves blood flow in the brain,stimulates the secretion of neurotrophic factors from the skeletal muscle,and promotes the growth,survival and proliferation of ,there is no uniform standard for the interventional are many links to be further improved,such as integration of individual differences and indexes in different brain regions,procedures for testing physical conditions(cardiovascular and lung diseases),to enhance the reliability of relevant parameters.
0 引言 Introduction
认知老化是一种增龄性的认知功能衰退,集中表现在认知加工速度和工作记忆能力的下降,新型功能性近红外光谱技术(functional near-infrared spectroscopy,fNIRS)可以无创、实时监测大脑血氧含量,已广泛用于大脑皮质活动性的相关研究,在此基础上间接判断认知功能的改善及程度。运动可以通过增加前额叶皮质的功能活动性提高认知功能,其内部机制包括:运动增加大脑血流灌注,提高大脑血氧水平,为认知功能的改善提供必要的物质基础;其次,运动可以刺激骨骼肌分泌神经递质——神经营养因子,通过PGC-1α/FNDC5信号轴、组织蛋白酶B增强了现有神经元的生长、存活和增殖。当前对运动改善认知功能的研究较为广泛,文章综述了基于近红外光谱技术的运动对老年人认知功能的提高及其内置机制,为改善认知功能的科学运动方案的制定提供理论参考。
1 资料和方法 Data and methods
1.1 资料来源 通过检索PubMed、WOS、中国知网、万方数据库,2000年1月到2019年7月发表的相关文献,以“exercise、near-infrared spectroscopy、cognition、elderly or older adults、cathepsin B、brain-derived neurotrophic factor”为英文检索词,“运动,近红外光谱,认知,老年人,组织蛋白酶B,脑源性神经营养因子”为中文检索词。
1.2 纳入和排除标准
纳入标准:基于近红外光谱分析技术的、运动改善老年人认知相关的文章。
排除标准:研究内容重复及研究内容无关的文章。
文章来源:《运动精品》 网址: http://www.ydjpzz.cn/qikandaodu/2020/0824/619.html